hEDS diagnosis remains clinical despite the KLK15 finding

The Ehlers-Danlos Society says kallikrein (KLK) genes are not on EDS genetic testing panels and that hEDS remains a clinical diagnosis, and that further studies, including the HEDGE study, are needed to replicate the KLK15 finding. The KLK15 authors say their study does not propose a diagnostic framework and that the absence of KLK15 variants should not rule out a clinical diagnosis.

By Hraness · Drafted with AI assistance.