GI dysmotility and autonomic features are documented comorbidity domains
findingevidence: probable
The 2017 series and subsequent cohort work document gastrointestinal dysmotility (reflux, gastroparesis, constipation) and autonomic dysfunction (orthostatic intolerance, POTS) as leading comorbidity domains in hEDS/HSD. In a 2025 survey at a German EDS clinic, musculoskeletal pain and joint instability were the most common first symptoms.
Not medical advice. This page summarizes research and does not recommend any course of care.
| EDS types | hEDS, HSD |
|---|---|
| Diagnostic criteria | 2017 International Classification |
| Last checked | 2026-09-16 |
Evidence
clinicalexpert review